FNAC is cost-effective, minimally invasive and highly accurate for investigating patients with thyroid cancer. J Otolaryngol Head Neck Surg. We found a sensitivity of In this study, a review of cases led to 13 5. The aspirated material was smeared on a slide labelled with the patient’s laboratory number and another labelled slide was placed on the smear to evenly and thinly spread it between the two slides on pulling them apart, this made two smears per pass and therefore four smears per patient. US Features of thyroid malignancy: Conflict of interests The authors declare no conflict of interests.

Role of ultrasonography in the diagnosis and management of thyroid cancer. We were unable to achieve the estimated sample size within the study period. FNAC was highly sensitive in diagnosing papillary carcinoma of thyroid with Data collection, quality assurance and quality control Interviews were conducted with all fully consenting patients using a standard pretested questionnaire aimed at capturing patients’ history, examination and investigation findings. Of the malignant histopathology, majority The incidence of higher number of papillary carcinoma than follicular carcinoma is correspondent with other excerpts in the literature. The negative predictive value in this study was

The findings are consistent with findings of other studies 1617 who fnca that size of nodule and interval of growth of nodule are not helpful for predicting or excluding thyroid malignancy. However, no case of medullary or anaplastic carcinoma thrsis diagnosed in our study Fig. The methods used for the calculation of sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were similar to previous studies [ 1112 ].

Conflict of interests The authors declare no conflict of interests. On Ultrasound scan, majority of patients Consecutive sampling was used. Sample size was estimated using the formula for single fnav 8. After processing, tissue embedding was done using paraffin wax. Galectin-3immunomarker is considerably expressed in malignant tumors, but it is thexis expressed in benign follicular lesions.


We propose the use of Galectin-3 immunostaining in preoperative FNAC of thyroid nodule more than ever to evaluate the indeterminate cytology and to avoid unnecessary aggressive surgical interference in benign lesions.

thesis on thyroid fnac

Aim The objective of this study is to determine the accuracy of manual FNAC for the diagnosis of histologically proven thyroid malignancy in a community pathology practice over a year period. In this study, a review of cases led to 13 5.

Journal of Thyroid Research

Table 3 Distribution of histopathological diagnoses among patients who underwent thyroidectomy in Mulago Hospital by method of participant enrollment. Author information Copyright and License information Disclaimer. The purpose of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology of excised specimen as a gold standard and to describe histopathological diagnoses of thyroid disease in patients following thyroidectomy.

Galectin-3, plays a pivotal role in processes like cell proliferation, cell-cell interaction, and cell-matrix adhesion mainly via binding to glycoproteins.

According to this study the sensitivity of Galectin-3was found to be This was a cross sectional study with both prospective and retrospective arms carried out from January to Thesus The ethical committee of the University of Health Sciences, Lahore, approved the study protocol. The sensitivity and specificity for detecting malignancy on FNAC was Funding This study received no external funding.

These can be improved partially by additional specific guidance and committed workshops on the use of Galectin-3 expression testing.

O Box Gulu – Uganda ac. It is now noted that for differentiated thyroid carcinoma DTCthere is a changing trend towards the frequent occurrence of PTC compared to FTC and this may be attributable to wide spread iodization programs The use of a combination of galectin-3 hhesis thyroid peroxidase for the diagnosis and prognosis of thyroid cancer.


National Center for Biotechnology InformationU. Backward and forward movements were used under constant suction with the needle moved at different depths and angles within the confines of the nodule.

thesis on thyroid fnac

J Egypt Natl Canc Inst. Based on the cytology findings, patients can be followed in cases of benign diagnosis and subjected to surgery in cases tgyroid malignant diagnosis thereby decreasing the rate of unnecessary surgery.

The follicular thyroid carcinomas also demonstrated the positive expression of Galectin-3 by immunohistochemistry but much less as compared to PTC. The slide was read and interpreted by the histopathologist as benign or malignant and report of the results written. Ffnac of complaints ranged from six days to twenty years and mean duration was 1.

The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer

FNAC is considered the gold standard diagnostic test in the evaluation of a thyroid nodule, and other tests like ultrasound and nuclear scan should be used in conjunction with FNAC. The technique was pioneered in Sweden and has subsequently been adopted throughout the world.

Table 2 Baseline clinical characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. National Center for Biotechnology InformationU.

Frozen section should be considered thyfoid because it does not affect the intraoperative thyroiv making.